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According to the FDA label, no clinically relevant pharmacokinetic changes occur across the spectrum of renal impairment, including end-stage renal disease, and no dose adjustment is required

Benefits of the maintenance approach include sustained appetite regulation, continued metabolic support, fewer side effects at lower doses, and easier dose escalation if weight begins to creep

Protein preserves lean muscle, which is your most metabolically active tissueevery pound of muscle you maintain burns 6 calories per day at rest, while fat burns only 2 calories daily

Furthermore, selenium supplementation can prevent bone marrow lesions and promote repair, offering preventive and therapeutic benefits for conditions like Keshan disease, KashinBeck disease, and arthritis [154,155]